Fearun9033

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Fearun9033

Age/Gender: 19, Male
Location: Montreal, Canada
Job: Medical student

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Fearun9033

Holiday advice from med student!

Posted by Fearun9033 Dec. 2, 2009 @ 2:48 PM EST

Holidays are coming soon!!! Yay =) This means that finals are here, Christmas is coming aaaaand... alcohol.

So, besides the very important "DON'T DRINK AND DRIVE" things (which you should really heed), there is also another thing to remember!

DO NOT DRINK ALCOHOL AND TAKE TYLENOL

Tylenol is the brand name for a pain-killer drug containingacetaminophen

(paracetamol).
Paracetamol

In short, what happens is that it kills your liver. Scientifically, it causes liver cirrhosis.
Now, this doesn't seem so bad until you find out that there is no cure for liver cirrhosis. There is no artificial liver (like artificial heart), there's no dialysis machine (like for the kidneys), etc. You will basically die a slow and painful death if you kill your liver.

However, a liver transplant will save you! The bad news? The liver is the second rarest organ after the heart. So not only will you die a slow and painful death, you will do so while desperately looking at the transplant list NOT moving very fast.

So, drink responsibly! And if you get a headache, don't take any painkillers!!! Alcohol causes a lot of reactions with a lot of stuff.
So if you do drink a lot, just go to bed and drink lots of water.

Have a good Holiday season everyone =)

For those interested, here is what happens scientifically:

Normally, the enzyme glucuronyl transferase latches onto acetaminophen and removes it from the body.
If there is an overdose acetaminophen, the body engages a backup mechanism: it produces more Cytochrome P-450 (Phase I enzymes) which modifies acetaminophen into NAPQI, a substance that is highly reactive and toxic to the liver.

To prevent liver damage, the enzyme Glutathione-S-Transferase eliminates the substance in the urine. This enzyme requires glutathione as a precursor.

Alcohol complicates the matter as it induces the formation of cytochrome P450 in the body.
Hence, if you take alcohol and tylenol, more of it will be transformed into NAPQI. Now, you know what happens!

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